EXTRABROC® Stable High Conversion Sulforaphane
EXTRABROC® is a patented functional food ingredient system comprised of three main modules: standardized broccoli seed water extract, active black myrosinase, and a patented stabilization system. Its core objective is to increase the body's effective sulforaphane production (ESY). It transforms the long-standing industry debate of "how high is the content?" into a more fundamental question: "How much active sulforaphane can the human body ultimately produce?" This makes the ingredient's functional capabilities measurable, verifiable, and deliverable.
EXTRABROC® Broccoli Seed Water Extract
EXTRABROC® stable high-conversion sulforaphane production raw materials form a complete and verifiable causal chain: seed source locking input → stable enzyme activity preservation → enzyme activity promoting conversion → conversion to ESY → clinical validation of ESY.
Product Name: Broccoli Seed Water Extract
Other names: Broccoli extract, Broccoli seed extract, Kale extract, Sulforaphane, etc.
Appearance: White to yellowish-brown powder
Extraction source: Broccoli seeds
Product specifications: sulforaphane 5-20%, sulforaphane 0.4-13%; other specifications can be customized.
Industry Status & Pain Points
• First generation: Glucosamine extract (stable but conversion is uncontrollable)
• Second generation: Pure sulforaphane raw material (no conversion required but extremely unstable, requires cold chain storage)
• Third generation: Sulforaphane production raw materials (such as EXTRABROC®, which is stable in vitro, highly efficient in vivo, and clinically validated).
Commercially available broccoli seed water extracts may meet USP/GRAS and new food ingredient requirements, yet still face challenges such as **limited efficacy, poor room-temperature stability, and insufficient clinical evidence.
The key is whether they can stably convert sufficient sulforaphane at compliant dosages, demonstrate proven human benefits, and maintain long-term stability for industrial production.
Break Down Barriers
Barrier 1: Own high-content seed sources, securing the starting point for ESY
The broccoli seed-specific variety FS08/FS314 was independently bred, with a GRN content of ≥5.5%, which is 2-3 times higher than that of ordinary commercial varieties[15], ensuring high purity, high consistency and long-term stable supply from the source.
Barrier 2: High stability at room temperature for 24 months, laying the foundation for ESY
By using a patented stabilization system (Chinese Invention Patent ZL202211488217.2[16], Japanese Patent No. 7379533[17]) to protect enzyme activity and precursors, room temperature storage for 24 months is achieved: completely eliminating reliance on cold chain.
Barrier 3: Intragastric enzymatic conversion rate ≥55%, ending the "intestinal lottery"
Enzyme-free products completely delegate the conversion task to the consumer's gut microbiota, with an average conversion rate of only about 10%, and individual differences of up to 40 times [Cancer Prev Res (Phila). 2012 April ; 5(4): 603-611] . The product effect is like a "lottery" ; turning "lottery that varies from person to person" into "certainty that everyone can predict".
Barrier 4: Clinical Evidence to Verify ESY's Human Value
More than 10 human clinical trials and real-world studies have been completed in multiple centers, providing authoritative endorsement of its high-end scientific efficacy.
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Clinical Registration Number |
Project Name |
Study Type |
|
NCT03932136 |
Sulforaphane Reduces Risk of Psychiatric Disorders (DROPS) (300 participants) |
Multicenter, randomized, double-blind, placebo-controlled |
|
NCT05145270 |
A comparative study on the efficacy and safety of sulforaphane or rTMS combined with itopride in treating patients with severe depression who did not respond well to initial treatment (180 participants) |
Randomized, double-blind, placebo-controlled |
|
NCT05148169 |
A Preliminary Study on the Application of Adding Sulforaphane and Nicotinic Acid to SSRIs in the Skin Flushing Reaction Test for Severe Depression (150 Participants) |
Randomized, double-blind, placebo-controlled |
|
ChiCTR2000028706 |
Study on the Efficacy, Safety and Related Mechanisms of Sulforaphane in the Adjuvant Treatment of Depressive Phase of Bipolar Disorder (100 Participants) |
Randomized, double-blind, placebo-controlled, parallel |
|
ChiCTR2100050687 |
The efficacy of sulforaphane in the adjunctive treatment of simple fatty liver and related research mechanisms |
Randomized, double-blind, placebo-controlled |
|
Ethical Review Approval Letter Number 2021-09 |
Development of a nutritional optimization pathway for the prevention and treatment of common mental disorders based on niacin skin flush testing（150 Participants） |
Real world study |
|
Ethical Review Approval Letter Number 2023-08-10 |
Translational Application of Sulforaphane in the Treatment of Autism Spectrum Disorder (ASD) |
Randomized, double-blind, placebo-controlled |
|
Ethical Review Approval Letter Number 2023-08-01-2 |
Research on the construction of a precise nutritional pathway for sulforaphane to regulate the risk of mental disorders based on niacin skin reaction detection |
Real world study |
|
(2024) China Ethics Review [Science] No. (K041) |
Research on the Mechanism of Sulforaphane in Improving Autism Spectrum Disorder |
Randomized, double-blind |
|
(2025) China Ethics Review [Science] No. (K023) |
Research on the Mechanism of Sulforaphane in Improving Negative Symptoms and Cognitive Function in Patients with Schizophrenia |
Randomized, double-blind, placebo-controlled |
|
2026023K |
Individualized Intervention for Bladder Cancer Recurrence: Roles of Genotype and Dietary Isothiocyanate Metabolism |
- |
3 of them were registered with the North American Clinical Trial Registry, and 2 of them were registered with the Chinese Clinical Trial Registry. (By March 2026)
The perspectives of industry evolution and industry pain points , EXTRABROC® enables the industry to leap from "providing ingredients" to "delivering functions . " EXTRABROC® stands at the origin of third-generation sulforaphane production raw materials . EXTRABROC®'s solution is to shift the competitive dimension from "input" to "output" and propose a comprehensive indicator of "Effective Sulforaphane Yield (ESY)" in the human body.
Applications
Mechanism of action : It targets and activates the Nrf2 pathway, the core defense system of the human body, to achieve health regulation at the cellular level;
Application directions : Healthy aging, sleep support, glucose and lipid metabolism, sports nutrition and weight management.
Dosage Forms : Compatible with solid dosage forms such as tablets and capsules, semi-solid dosage forms such as powders, pastries, and energy bars, and liquid beverages such as drinks and oral liquids (solutions can be provided). Widely used in dietary supplements, medical nutrition foods, sports nutrition products, and functional beverages.
why choose us
Compliance and Qualification
• Compliant with the announcement of new food raw materials containing broccoli seed water extract
• US FDA GRAS registration and certification
• Meets USP-NF standards
• The production base is certified by five major systems: GMP, ISO22000, HACCP, HALAL, and KOSHER.
• Extracted entirely with pure water, with no organic solvent residue.
• Exclusive pretreatment technology ensures high safety: Removes hazardous impurities such as allyl isothiocyanate, resulting in greater safety.
• Non-GMO, with all 500+ indicators for pesticide residues, microorganisms, and heavy metals meeting standards.
Capacity, delivery and other services
Stable production capacity: 50 tons/year, supporting large-scale orders.
Efficient delivery: Establish a 3-7 day rapid response and shipping system
Full traceability: From seed to finished product, the entire process is quality-controlled and traceable.
Custom formulation service: We customize raw material content, dosage form, and compounding schemes according to customer needs.
Process and testing support: We assist in guiding the production process and can provide third-party testing reports (such as HPLC chromatograms) on glucosinolate/glucosinolate content.
